Rare Malignant Skin Tumors by Franco Rongioletti Irina Margaritescu & Bruce R Smoller

Author:Franco Rongioletti, Irina Margaritescu & Bruce R Smoller
Language: eng
Format: epub
Publisher: Springer New York, New York, NY

Fig. 38.2Retiform hemangioendothelioma. The arborizing blood vessels are arranged in a pattern reminiscent of the normal rete testis architecture

Fig. 38.3Retiform hemangioendothelioma. The arborizing blood vessels are lined by monomorphic endothelial cells with prominent protuberant nuclei having a characteristic hobnail-like appearance

Fig. 38.4A vascular tumor with mixed features of Dabska’s tumor and retiform hemangioendothelioma showing positivity with CD31

Immunohistochemically, the tumor cells react with endothelial markers such as CD31 (Fig. 38.4), CD34, factor VIII-related antigen, and ERG. Staining for CD34 is usually stronger than that for other vascular markers. Claudin-5, a tight-junction protein, has recently been proposed as a reliable vascular marker. Cytokeratins and smooth muscle actin are negative. Most lymphatic markers, including podoplanin (D2-40) and VEGFR-3, are negative. In one case report, HHV8 DNA sequences were claimed to be detected, but in general experience, RH are negative for HHV8.

Download

Copyright Disclaimer:
This site does not store any files on its server. We only index and link to content provided by other sites. Please contact the content providers to delete copyright contents if any and email us, we'll remove relevant links or contents immediately.